Mathematics

Mathematics of diffusive signaling and the role of receptor clustering in chemoreception.

Speaker: 
Alan Lindsay
Date: 
Wed, May 12, 2021
Location: 
UBC
Online
Conference: 
PIMS Workshop on New Trends in Localized Patterns in PDES
Abstract: 

Cells receive chemical signals at localized surface receptors, process the data and make decisions on where to move or what to do. Receptors occupy only a small fraction of the cell surface area, yet they exhibit exquisite sensory capacity. In this talk I will give an overview of the mathematics of this phenomenon and discuss recent results focusing on receptor organization. In many cell types, receptors have very particular spatial organization or clustering - the biophysical role of which is not fully understood. In this talk I will explore how the number and configuration of receptors allows cells to deduce directional information on the source of diffusing particles. This involves a wide array of mathematical techniques from asymptotic analysis, homogenization theory, computational PDEs and Bayesian statistical methodologies. Our results show that receptor organization plays a large role in how cells decode their environmental situation and infer the location of distant sources.

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Non-hexagonal lattices from a two species interacting system

Speaker: 
Xiaofeng Ren
Date: 
Wed, May 12, 2021
Location: 
UBC
Online
Conference: 
PIMS Workshop on New Trends in Localized Patterns in PDES
Abstract: 

A two species interacting system motivated by the density functional theory for triblock copolymers contains long range interaction that affects the two species differently. In a two species periodic assembly of discs, the two species appear alternately on a lattice. A minimal two species periodic assembly is one with the least energy per lattice cell area. There is a parameter b in [0,1] and the type of the lattice associated with a minimal assembly varies depending on b. There are several thresholds defined by a number B=0.1867... If b is in [0, B), a minimal assembly is associated with a rectangular lattice; if b is in [B, 1-B], a minimal assembly is associated with a square lattice; if b is in (1-B, 1], a minimal assembly is associated with a rhombic lattice. Only when b=1, this rhombic lattice is a hexagonal lattice. None of the other values of b yields a hexagonal lattice, a sharp contrast to the situation for one species interacting systems, where hexagonal lattices are ubiquitously observed.

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The conserved Swift-Hohenberg equation and crystallization

Speaker: 
Edgar Knobloch
Date: 
Wed, May 12, 2021
Location: 
UBC
Online
Conference: 
PIMS Workshop on New Trends in Localized Patterns in PDES
Abstract: 

The phase-field model, also known as the conserved Swift-Hohenberg equation, provides a useful model of crystallization that is derivable from the more accurate dynamical density functional theory. I will survey the properties of this model focusing on spatially localized structures and their organization in parameter space. I will highlight the role played by conserved mass and discuss the role played by these structures in the thermodynamic limit in both one and two spatial dimensions. I will then discuss dynamic crystallization via a propagating crystallization front. Two types of fronts can be distinguished: pulled and pushed fronts, with different properties. I will demonstrate, via direct numerical simulation, that the crystalline structures deposited by a rapidly moving front are not in thermodynamic equilibrium and so become disordered as they age. I will conclude with a discussion of a two-wavelength generalization of the model that exhibits quasicrystalline order in both two and three dimensions and of the associated spatially localized structures with different quasicrystalline motifs. The possible role of metastable spatially localized structures in nucleating crystallization will be highlighted.

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Traveling pulses with oscillatory tails, figure-eight stack of isolas, and dynamics in heterogeneous media

Speaker: 
Yasumasa Nishiura
Date: 
Wed, May 12, 2021
Location: 
UBC, Vancouver, Canada
Online
Conference: 
PIMS Workshop on New Trends in Localized Patterns in PDES
Abstract: 

The interplay between 1D traveling pulses with oscillatory tails (TPO) and heterogeneities of bump type is studied for a generalized three-component FitzHugh-Nagumo equation. We first present that stationary pulses with oscillatory tails (SPO) forms a “snaky" structure in homogeneous space, then TPO branches take a form of "figure-eight-like stack of isolas" located close to the snaky structure of SPO. Here we adopt voltage-difference as a bifurcation parameter. A drift bifurcation from SPO to TPO can be found by introducing another parameter at which these two solution sheets merge. As for the heterogeneous problem, in contrast to monotone tail case, there appears a nonlocal interaction between the TPO and the heterogeneity that creates infinitely many saddle solutions. The response of TPO shows a variety of dynamics including pinning and depinning processes in addition to penetration and rebound. Stable/unstable manifolds of these saddles interact with TPO in a complex way, which causes a subtle dependence on the initial condition and a difficulty to predict the behavior after collision even in one-dimensional space. Nevertheless, for 1D case, a systematic global exploration of solution branches (HIOP) induced by heterogeneities, and the reduction method to finite-dimensional ODEs allow us to clarify such a subtle dependence of initial condition and detailed mechanism of the transitions from penetration to pinning and pinning to rebound from dynamical system view point. It turns out that the basin boundary between two different outputs against the heterogeneities forms an infinitely many successive reconnections of heteroclinic orbits among those saddles as the height of the bump is changed, which causes the subtle dependence of initial condition. This is a joint work with Takeshi Watanabe.

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Symmetries and bifurcations in non-local cell adhesion models

Speaker: 
Thomas Hillen
Date: 
Thu, May 13, 2021
Location: 
UBC
Online
Conference: 
PIMS Workshop on New Trends in Localized Patterns in PDES
Abstract: 

Cellular adhesion is one of the most important interaction forces between cells and other tissue components. In 2006, Armstrong, Painter and Sherratt introduced a non-local PDE model for cellular adhesion, which was able to describe known experimental results on cell sorting and pattern formation. The pattern formation arises through non-local attractive interactions of the cells. In this talk I will analyse the underlying symmetries and bifurcations that lead to the observed patterns. (joint work with A. Buttenschoen).

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Patterns, waves and bufurcations in cell migration

Speaker: 
Leah Edelstein-Keshet
Andreas Buttenschoen
Date: 
Thu, May 13, 2021
Location: 
UBC
Online
Conference: 
PIMS Workshop on New Trends in Localized Patterns in PDES
Abstract: 

Cell migration plays a central roles in embryonic development, wound healing and immune surveillance. In 2008, Yoichiro Mori, Alexandra Jilkine and LEK published a reaction-diffusion model for the initial step of cell migration, the front-back chemical polarization that sets a cell's directionality. (More detailed mathematical properties of this model were described by the same group in 2011.) Since then, progress has been made in investigating how that simple "wave-pinning" mechanism is shaped and tuned by feedback from other proteins, from the cell's environment (extracellular matrix), from interplay with larger signaling networks, and from cell-cell interactions. In this talk, we will describe some of this progress and mathematical questions that arise. In particular, AB will demonstrate how his numerical PDE bifurcation analysis has helped us to understand how cells repolarize to reverse their direction of motion.

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Towards optimal spectral gaps in large genus

Speaker: 
Michael Lipnowski
Date: 
Thu, May 13, 2021
Location: 
Zoom
Online
Conference: 
Pacific Dynamics Seminar
Abstract: 

I'll discuss recent joint work with Alex Wright (arXiv:
2103.07496
) showing that typical large genus hyperbolic surfaces have first
Laplacian eigenvalue at least 3/16−ϵ.

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Classification and rigidity for group von Neumann algebras.

Speaker: 
Adrian Ioana
Date: 
Tue, May 4, 2021
Location: 
Online
University of Regina
Abstract: 

Any countable group G gives rise to a von Neumann algebra L(G). The classification of these group von Neumann algebras is a central theme in operator algebras. I will survey recent rigidity results which provide instances when various algebraic properties of groups, such as the presence or absence of a direct product decomposition, are remembered by their von Neumann algebras. I will also explain the strongest such rigidity results, where L(G) completely remembers G, and discuss some of the open problems in the area.

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Remarks on multi-marginals entropic optimal transport and Sinkhorn algorithm

Speaker: 
Guillaume Carlier
Date: 
Thu, May 6, 2021
Location: 
Zoom
Online
Conference: 
Kantorovich Initiative Seminar
Abstract: 

Entropic optimal transport has received a lot of attention in recent years and has become a popular framework for computational optimal transport thanks to the Sinkhorn scaling algorithm. In this talk, I will discuss the multi-marginal case which arises in different applied contexts in physics, economics and machine learning. I will show in particular that the multi-marginal Schrödinger system is well posed (joint work with Maxime Laborde) and that the multi-marginal Sinkhorn algorithm converges linearly.

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Random Hyperbolic Surfaces Via Flat Geometry

Speaker: 
Aaron Calderon
Date: 
Thu, May 6, 2021
Location: 
Online
Zoom
PIMS, University of Washington
Conference: 
Pacific Dynamics Seminar
Abstract: 

Mirzakhani gave an inductive procedure to build random hyperbolic surfaces by gluing together smaller random pieces along curves. She proved that as the length of the gluing curve grows, these families equidistribute in the moduli space of hyperbolic surfaces. In this talk, I’ll explain how the conjugacy (exposited in James’s talk) between the earthquake and horocycle flows provides a template for translating equidistribution results for flat surfaces into equidistribution results for hyperbolic ones. Using this correspondence, we address Mirzakhani’s twist torus conjecture and exhibit new limiting distributions for hyperbolic surfaces built out of symmetric pieces. This is joint work (in progress) with James Farre.

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