Programmable Human Organoids via Genetic Design and Engineering

Speaker: Mo Ebrahimkhani

Date: Wed, Oct 13, 2021

Location: PIMS, University of British Columbia, Zoom, Online

Conference: Mathematical Biology Seminar

Subject: Mathematics, Mathematical Biology

Class: Scientific


Synthetic biology offers bottom-up engineering strategies that intends to understand complex systems via design-build-test cycles. In development, gene regulatory networks emerge into collective cellular behaviors with multicellular forms and functions. Here, I will introduce a synthetic developmental biology approach for tissue engineering. It involves building developmental trajectories in stem cells via programmed gene circuits and network analysis. The outcome of our approach is decoding our own development and to create programmable organoids with both natural or artificial designs and augmented functions.