Cell symmetry breaking for movement through a mechanochemical mechanism

Speaker: Calina Copos

Date: Wed, Apr 28, 2021

Location: Zoom, Online, PIMS, University of British Columbia

Conference: Mathematical Biology Seminar

Subject: Mathematics, Mathematical Biology

Class: Scientific


To initiate movement, cells need to form a well-defined "front" and "rear" through the process of cellular polarization. Polarization is a crucial process involved in embryonic development and cell motility and it is not yet well understood. Mathematical models that have been developed to study the onset of polarization have explored either biochemical or mechanical pathways, yet few have proposed a combined mechano-chemical mechanism. However, experimental evidence suggests that most motile cells rely on both biochemical and mechanical components to break symmetry. I will describe a mechano-chemical mathematical model for emergent organization driven by both cytoskeletal dynamics and biochemical reactions. We have identified one of the simplest quantitative frameworks for a possible mechanism for spontaneous symmetry breaking for initiation of cell movement. The framework relies on local, linear coupling between minimal biochemical stochastic and mechanical deterministic systems; this coupling between mechanics and biochemistry has been speculated biologically, yet through our model, we demonstrate it is a necessary and sufficient condition for a cell to achieve a polarized state.