A Quantitative Systems Pharmacology Model of the Immune Response to SARS-COV-2

Speaker: 
Wei Dai
Rohit Rao
Date: 
Wed, Jun 24, 2020
Location: 
Zoom
Conference: 
CAIMS - PIMS Coronavirus Modelling Conference
CRG: 
Abstract: 

Rapid development of a QSP model to support novel COVID-19 therapies. We intend to publish this model quickly to encourage community feedback. The simulated dynamics of immune response are modeled by describing viral activation of innate and adaptive immune processes involving both pro-inflammatory mediators regulating viral clearance and cell damage (e.g. neutrophils and cytotoxic lymphocytes) as well as counter-regulatory immune suppressive mediators (e.g. Treg cells and IL-10).

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