The Emerging Roles and Computational Challenges of Stochasticity in Biological Systems

Linda Petzold
Fri, Mar 28, 2014
PIMS, University of British Columbia
PIMS/UBC Distinguished Colloquium

In recent years it has become increasingly clear that stochasticity plays an important role in many biological processes. Examples include bistable genetic switches, noise enhanced robustness of oscillations, and fluctuation enhanced sensitivity or “stochastic focusing". Numerous cellular systems rely on spatial stochastic noise for robust performance. We examine the need for stochastic models, report on the state of the art of algorithms and software for modeling and simulation of stochastic biochemical systems, and identify some computational challenges.