Mathematics

In Bernoulli bond percolation, we delete or retain each edge of a graph independently at random with some retention parameter p and study the geometry of the connected components (clusters) of the resulting subgraph. For lattices of dimension d>1, percolation has a phase transition, with a infinite cluster emerging at a critical probability pc(d). It is believed that critical percolation at and near the critical probability exhibits rich, fractal-like geometry that is expected to be approximately independent of the choice of lattice but highly dependent on the dimension d. In particular, various qualitative distinctions are expected between the low dimensional case d<6, the high-dimensional case d>6, and the critical case d=6, but this remains poorly understood particularly in dimensions d=3,4,5,6.

In this course, I will give an overview of of what is known about critical percolation, focussing on the non-planar models and including a detailed treatment of recent advances in long-range and hierarchical models for which various aspects of intermediate-dimensional critical phenomena can now be understood rigorously.

No prior knowledge of percolation will be assumed.

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The heat kernel is the fundamental solution to a parabolic partial differential equation. From a probabilistic perspective, the heat kernel is the transition probability density of a stochastic process. Harnack inequalities and functional inequalities such as Poincare and Sobolev inequalities provide tools to understand the relationship between the behavior of the heat kernel and the geometry of the underlying space. An important feature of the approach using functional inequalities is its robustness under perturbations.

The study of the heat kernel and its estimates has produced fruitful interactions between the fields of Analysis, Geometry, and Probability. One of the goals of this course is to illustrate these interactions of heat kernel estimates with functional inequalities, boundary trace processes, quasisymmetric maps, circle packings, the time change of Markov processes, Doob's h-transform, and estimates of harmonic measure or exit distribution.

The setting for this course is a symmetric Markov process which is equivalentlydescribed using a Dirichlet form. This course will contain an introduction to the theory of Dirichlet forms. This theory will be used to construct and analyze Markov processes. This course will survey both classical results and recent progress in our understanding of heat kernel estimates and Harnack inequalities.

• Lecture 1
• Lecture 2
• Lecture 3
• Lecture 4
• Lecture 5
• Lecture 6
• Lecture 7
• Lecture 8
• Lecture 9
• Lecture 10
• Lecture 11
• Lecture 12
• Lecture 13
• Lecture 14
• Lecture 15
• Lecture 16

The heat kernel is the fundamental solution to a parabolic partial differential equation. From a probabilistic perspective, the heat kernel is the transition probability density of a stochastic process. Harnack inequalities and functional inequalities such as Poincare and Sobolev inequalities provide tools to understand the relationship between the behavior of the heat kernel and the geometry of the underlying space. An important feature of the approach using functional inequalities is its robustness under perturbations.

The study of the heat kernel and its estimates has produced fruitful interactions between the fields of Analysis, Geometry, and Probability. One of the goals of this course is to illustrate these interactions of heat kernel estimates with functional inequalities, boundary trace processes, quasisymmetric maps, circle packings, the time change of Markov processes, Doob's h-transform, and estimates of harmonic measure or exit distribution.

The setting for this course is a symmetric Markov process which is equivalentlydescribed using a Dirichlet form. This course will contain an introduction to the theory of Dirichlet forms. This theory will be used to construct and analyze Markov processes. This course will survey both classical results and recent progress in our understanding of heat kernel estimates and Harnack inequalities.

• Lecture 1
• Lecture 2
• Lecture 3
• Lecture 4
• Lecture 5
• Lecture 6
• Lecture 7
• Lecture 8
• Lecture 9
• Lecture 10
• Lecture 11
• Lecture 12
• Lecture 13
• Lecture 14
• Lecture 15
• Lecture 16

Concern for the impact of climate change on the spread and severity of infectious disease is widespread. For long-term management of global health, we need to consider parasite evolution under such environmentalchange. Vector-borne diseases are likely to be particularly affected bychanging climates due to the sensitivity of ectothermic vectors to temperature.Here, I present a work-in-progress of an age-structured SI model to represent the ecological dynamics of a general vector-borne disease, incorporating temperature-dependent parameters. Using sequential invasion analyses, the evolutionary trajectory of within-host parasite replication rate, and thus virulence, can then be predicted under a specified heating regime.

Following a vaccine inoculation or disease exposure an immune response develops in time, where the description of its time evolution poses an interesting problem in dynamical systems. The principal goal of theoretical immunology is to construct models capable of describing long term immunological trends from the properties and interactions of its elementary components. In this talk I will give a brief description of the human immune system and introduce a simplified version of its elementary components. I will then discuss our contributions to the field achieved through my postdoctoral work with Dr. Jane Heffernan at York University. I will focus on our mechanistic modelling work describing vaccine-generated SARS-CoV-2 immunity and applications of our work towards understanding vaccination responses in people living with HIV. Finally, I will discuss our on-going work towards developing a machine learning public health platform capable of predicting immune response outcomes from repeated-dose immunological data.