Models for Cell Shape and Actin Filament Distributions

Leah Edelstein-Keshet
Tue, May 22, 2012
PIMS, University of British Columbia
Mathematical Cell Biology Summer Course
In this lecture I describe a model by Grimm et al (2003) Eur Biophys J 32: 563-577. The authors ask what processes might account for a parabolic density profile of actin seen across the front edge of a keratocyte. In an elegant coupled PDE model, they show that right and left growing actin filaments, competing for the actin branching complex Arp2/3 have solutions with the appropriate profile. I here consider one of the cases, that of local competition and slow capping of filaments, where the equations are fully analytically solvable in closed form.

You are missing some Flash content that should appear here! Perhaps your browser cannot display it, or maybe it did not initialize correctly.